Additive Antinociception between Intrathecal Sildenafil and Morphine in the Rat Formalin Test
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چکیده
منابع مشابه
Additive Antinociception between Intrathecal Sildenafil and Morphine in the Rat Formalin Test
The possible characteristics of spinal interaction between sildenafil (phosphodiesterase 5 inhibitor) and morphine on formalin-induced nociception in rats was examined. Then the role of the opioid receptor in the effect of sildenafil was further investigated. Catheters were inserted into the intrathecal space of male Sprague-Dawley rats. For induction of pain, 50 microL of 5% formalin solution ...
متن کاملCervicomedullary intrathecal injection of morphine produces antinociception in the orofacial formalin test in the rat.
BACKGROUND High cervical and medullary drug delivery has been advocated for the treatment of refractory head and neck pain in humans. Currently, parallel models in animals have not been developed to support this methodology. We combined an accepted animal model of pain of cranial origin with a novel technique of neuraxial drug delivery to address this issue. METHODS Male Wistar rats were impl...
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BACKGROUND The authors evaluated the effect of intrathecal mixture of ginsenosides with neostigmine on formalin-induced nociception and made further clear the role of the spinal muscarinic (M) receptors on the activity of ginsenosides. METHODS A catheter was located in the intrathecal space of male Sprague-Dawley rats. Pain was evoked by injection of formalin solution (5%, 50 µl) to the hindp...
متن کاملThe Effect of L-NAME on Morphine Antinociception in Formalin Test
Introduction: N- nitro-L-arginine methyl ester (L-NAME), one of the L-arginine analogs, has been specified as an inhibitor of nitric oxide synthase ( NOS).Nitric oxide synthase is an enzyme which leads to nitric oxide synthesis. Since nitric oxide has been known as a pain mediator, it can be said that L-NAME can decrease and relieve pain. In this research the effect of L-NAME on morphine antino...
متن کاملAnalgesic Effects of Intrathecal Curcumin in the Rat Formalin Test
BACKGROUND Curcumin has been reported to have anti-inflammatory, antioxidant, antiviral, antifungal, antitumor, and antinociceptive activity when administered systemically. We investigated the analgesic efficacy of intrathecal curcumin in a rat model of inflammatory pain. METHODS Male Sprague Dawley rats were prepared for intrathecal catheterization. Pain was evoked by injection of formalin s...
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ژورنال
عنوان ژورنال: Journal of Korean Medical Science
سال: 2008
ISSN: 1011-8934
DOI: 10.3346/jkms.2008.23.6.1033